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Drug Pathways & Tech

Drug Pathways & Tech

Drug Pathways & Tech

YUSIMRY: How SmithRx Offers a Low-Cost Humira Biosimila

Written by

Alan Pannier

Nov 16, 2023

Since launching in July 2023, SmithRx has continued expanding access to lower-cost biosimilars like Yusimry as part of its transparent PBM model.

SmithRx offers YUSIMRY, a Humira biosimilar, at more than 90 percent below Humira’s list price, delivering significant savings for employers and members.

Through its partnership with Mark Cuban Cost Plus Drug Company, PBC, SmithRx covers YUSIMRY for eligible members, with the medication available through the Cost Plus Drugs online mail-order pharmacy for $569.27 plus dispensing and shipping fees, compared to Humira’s list price of $6,922 per carton.

Unique to this collaboration, SmithRx members can apply their insurance benefits to further reduce out-of-pocket costs for YUSIMRY, making this Humira biosimilar an even more affordable option for patients and plan sponsors.

Unlike traditional pharmacy benefit managers (PBMs), SmithRx prioritizes transparency and up-front cost savings. Humira is often an employer’s top drug expense so offering a low-cost alternative will have a significant impact. We’re excited to work with Cost Plus Drugs to bring this biosimilar to our members – and significantly reduce costs for them and their employers.

Jake Frenz, CEO and founder of SmithRx

Humira remains one of the top-selling pharmaceutical in the world, and among the most expensive medications in America and is used to treat a range of auto-immune conditions including rheumatoid arthritis, Crohn’s disease, ulcerative colitis, and plaque psoriasis. Humira is used by more than 300,000 patients in the U.S., and biosimilar versions of it have only just come to market.

While multiple Humira biosimilars are now available in the market, SmithRx was the first PBM to make a Humira biosimilar accessible to patients at a low, transparent price.When a previous biosimilar was released in 2023, legacy PBMs made it available only through the standard model of high list prices coupled with opaque rebates.

Working with SmithRx, a transparent PBM, has been a great experience for Mark Cuban Cost Plus Drug Company. Their commitment to transparency and efficiency aligns perfectly with our mission to provide affordable and accessible medications to all. Together, we are forging a new path in the pharmaceutical industry, ensuring that patients receive the best care at the most reasonable costs.

Alex Oshmyansky, CEO of Mark Cuban Cost Plus Drug Company

On June 1, 2023, Mark Cuban Cost Plus Drug Company and Coherus Biosciences announced plans to offer Cost Plus Drug Company customers YUSIMRY (adalimumab-aqvh), a biosimilar of HUMIRA (adalimumab injection), in July 2023.

To learn more about how to save on YUSIMRY and other prescription medicines, contact SmithRx today.

YUSIMRY

Written by

Alan Pannier

Chief Strategy Officer, SmithRx

Alan oversees the company's pharmacy initiatives, including manufacturer relations, network management, and clinical solutions. His background includes clinical leadership roles at Magellan Health and Veridicus Health, as well as hands-on experience as a practicing pharmacist. Alan's academic credentials include an MBA and PharmD from Idaho State University, a Bachelor's in Chemistry and Business from Westminster College, and specialized training in managed care pharmacy. His comprehensive understanding of the industry drives SmithRx's innovative approach to pharmacy benefits management.

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SmithRx is on a mission to reduce the complexity and costs of pharmacy benefits with radical transparency and cutting-edge technology.

Pharmacy and Provider Line
Member Help

M-F 8am - 9pm ET; Saturday 11am - 4pm ET

© 2026 Smith Health, Inc
SmithRx Logo

SmithRx is on a mission to reduce the complexity and costs of pharmacy benefits with radical transparency and cutting-edge technology.

Pharmacy and Provider Line
Member Help

M-F 8am - 9pm ET; Saturday 11am - 4pm ET

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